NUMB and cancer: The induction expression of miR-200b-3p in PDA cells by quercetin may render the cancer stem cells less aggressive by a switch of the cell division mode from symmetric (self-renewing cancer stem cell division) to asymmetric division (differentiation to adipocytes, osteocytes, and chondrocytes), which is associated with reversing the elevated Notch levels with a simultaneous decrease in Numb protein levels [109].