AKT1 and breast carcinoma: The PI3K/Akt/mTOR signaling pathway overexpressed in breast cancer leads to cell growth and tumor proliferation, while curcumin inhibited the phosphorylation and activation of the Akt/mTOR signaling pathway, decreased the expression of the anti-apoptotic protein BCL-2, and promoted Bax expression and caspase-3 protein cleavage [85].