ADORA2A and Alzheimer disease: Considering that genetic-based AD studies may provide additional data regarding its pathogenesis; that ADORA2A and CYP1A2 are implicated in pathways such as in oxidative stress and caffeine metabolism, which are associated with AD; and also that the ADORA2A rs5760423 and CYP1A2 rs762551 variants have previously been linked to certain neurodegenerative disorders, which share biochemical and clinical similarities with AD, we performed a case–control study aiming to explore for any potential association between these two genetic variants (ADORA2A rs5760423 and CYP1A2 rs762551) and AD.