FADS1 and inflammatory bowel disease: Since FADS1 has also been implicated in IBD risk [16], we further contrasted the eQTL effects of the lead GWAS variant at the FADS1/2 locus, rs174564, on both genes, finding a much stronger association with FADS2 in blood and terminal ileum, and similar effect sizes but in opposite directions in the colon (Table S4).