Another experimental MS animal model, the Theiler’s Murine Encephalomyelitis Virus-Induced Demyelinating Disease (TMEV-IDD), is a viral model that mimics human MS in a variety of aspects that include chronic inflammation involving CD4+ and CD8+ T cells, B cells and myeloid cells; sex influenced disease course and symptomatology such as gait alterations and incontinence. The gene discussed is CD4; the disease is myeloid sarcoma.