For example, higher VD levels were associated with lower methylation of Wnt Family Member 5A (WNT5A) and dickkopf 1 (DKK1) genes in colorectal cancer patients and higher methylation of Retinoid X Receptor Alpha (RXRA) and NAD Synthetase 1 (NADSYN1) genes in breast cancer patients. This evidence concerns the gene RXRA and breast cancer.