In the present study, by employing mice with induced T2D, overexpression analysis, quantitative real-time polymerase chain reaction (qRT-PCR), and immunofluorescence staining, we investigated the expression and localization of Tfap2a during mouse oocyte meiosis and found that Tfap2a overexpression (Tfap2a-OE) regulates oocyte maturation, histone acetylation and lactylation, and the expression of p300. This evidence concerns the gene TFAP2A and type 2 diabetes mellitus.