Finally, although the high concentrations of Galectin-1 and -3 found in stromal and leukemia cells may impair our ability to completely inhibit them pharmacologically, our results suggest that such inhibitors could still be extremely useful, and probably not toxic, when combined with other therapies in both leukemias, and possibly other cancers, as reviewed in [51]. The gene discussed is LGALS1; the disease is leukemia.