Finally, because ST6Gal1 sialylation of N-glycans inhibits Galectin-1 binding but only some Galectin-3 binding [2], and we did not find evidence for a protective effect on BCP-ALL cells for extracellular stromal Galectin-1, this may simply reflect a greater contribution of extracellular Galectin-3. This evidence concerns the gene ST6GAL1 and acute lymphoblastic leukemia.