NFKB1 and renal cell adenocarcinoma: These results were consistent with a previous study using different ccRCC cell lines, which reported that ROS, cytokines, and other stresses could stimulate the continuous activation of pSTAT3, NF-kB, and MAPK signals [99,100,101,102,103,104] and promote the occurrence and development of RCC [100,105,106].