COL6A2 and periodontitis: Although Type I collagen detected in the proteome analysis did not have altered expression in Col6α2-KO and we did not perform collagen fibers analysis in the alveolar bone, we speculate that the altered properties we found in alveolar bone in the α2(VI) deficient mice, such as greater mineral density and disorganized ECM organization could be a factor for increased bone loss from periodontitis, however, other aspects of the function in Type VI collagen need to be studied in the future.