For example, using DURPO and LNCaP PCa cells as a model system, it was demonstrated that green tea polyphenol mixture (GTP) and EGCG treatments at 10 mg/L and 20 mM, respectively, induced the epigenetic reactivation and expression of tissue inhibitors of matrix metalloprotease-3 (TIMP-3), while decreasing the expression of enhancers of zeste homoloug 2 (EZH2) and its catalytic product, trimethylated histone H3, at lysine 27 (H3K27me3) [20]. This evidence concerns the gene TIMP3 and posterior cortical atrophy.