TERT and cancer: It has been previously shown that, in urothelial cancer as well as in other cancer types, these two C to T transitions mutations occurring at 124 bp and 146 bp upstream of the translation start codon generate new GGA(A/T) motifs that will allow E-twenty-six (ETS) transcription factors to bind, causing upregulation of TERT transcription and increased telomerase activity [29].