Finally, the recent discovery of the activation of the C228T TERT promoter allele in bladder cancer cells by the tripartite motif containing 28 (TRIM28) transcription factor which could be blocked by rapamycin analog opens new avenues for TERT-directed cancer therapies [45], possibly guiding in the future treatment decision making in patients with uTERTpm-positive tests and confirmed diagnosis of BC. This evidence concerns the gene TERT and cancer.