Cytokines are key mediators of AD pathophysiology, with Th2 cytokine activity predominant during the acute phase (e.g., IL-4, IL-5, IL-13, IL-31) [37], and Th1, Th17 and Th22 developing a role during the chronic phase [38,39,40,41,42]. The gene discussed is IL4; the disease is Alzheimer disease.