TNF and dry eye syndrome: Genes up-regulated by TNF-α in KCs (FDR < 0.10) but down-regulated by IDL, IDC and IDL + IDC included Rh family C glycoprotein (RHCG), S100 calcium binding protein A12 (S100A12), and baculoviral IAP repeat containing 3 (BIRC3) (Figure 4I).