KRT5 and Pruritus: We identified several pruritus-associated genes increased by IDL, IDC and IDL + IDC (e.g., BRCA2, KRT5, TCF4; Figure S6A), as well as several such genes decreased by IDL, IDC and/or IDL + IDC (e.g., IL2RG, TRPV3, TNFSF15, IL17RC; Figure S6A,F–I).