Glomerular overexpression of VCAM-1 and E-selectin induces the recruitment of Mac-1/podoplanin-positive macrophages, leading to the deposition of unmetabolized angiotensin-converting enzyme 2 (ACE2) and fibroblast growth factor 23 (FGF23) and inflammation-induced kidney injury in diabetics [86]. Here, FGF23 is linked to injury.