We found that the “Notch4-GATA-IRG” set of genes were over-expressed in tumor tissue by the same magnitude in LOCRC [fold change 1.09 (95% CI 1.07–1.12)] and in EOCRC [fold change 1.08 (95% CI 1.06–1.12)] (ANOVA interaction p = 0.71). The gene discussed is NOTCH4; the disease is neoplasm.