GPBAR1 and liver disorder: However, to our knowledge, very few studies have correlated their modifications in the brain with metabolic dysfunctions linked to diet-induced liver diseases: Jena and colleagues, for instance, reported that a fructose, palmitate, and cholesterol (FPC)-enriched diet reduced FXR and TGR5 signaling in the brain after eight months of treatment and induced a neuroinflammation [36,37], whereas Czarnecka et al. [35] showed a buildup of BAs in the blood and a reduction in the expression of mRNAs coding for FXR in the hippocampus and cerebellum of rat with thioacetamide-induced acute liver failure.