Some of the BcR engagements operate constantly during the disease, as is the case for self-antigens delivering signals to a polyreactive BcR or for autonomous signaling, whereas others are intermittent, as is the case for antigens of pathogens, which can deliver stimulatory signals during infections, although cross-reacting epitopes of apoptosis-related antigens can continue to stimulate the leukemic clone in the absence of pathogens. Here, BCR is linked to infection.