The notion of clonal hematopoiesis is also compatible with the frequent observation of oligoclonal B cell accumulations, in addition to the major B cell clone, in both MBL and CLL [252,253,254] and explains the relatively frequent occurrence of DLBCL and HL with IGHV-IGHD-IGHJ gene rearrangements discordant from that of CLL cells. This evidence concerns the gene IGHD and diffuse large B-cell lymphoma.