In mice, CD5+ B cells are numerous in the peritoneal cavity (albeit with differences in the various strains of mice); express a particular BcR repertoire; produce polyreactive antibodies (i.e., antibodies reacting with several antigens including self-antigens) mainly of the IgM isotype, as many CLL clones do; and give origin to lymphoproliferative disorders in certain experimental models (see below). This evidence concerns the gene CD40LG and lymphoproliferative syndrome.