AR and posterior cortical atrophy: Androgen stimulation in the prostate tissue was found to mediate a high expression of the fusion gene of the AR-responsive TMPRSS2 gene, and the ERG was proposed to increase the oncogenic signaling from its reciprocal suppression of AR, which may ultimately result in a resistance to ADT and the induction of the EZH2-mediated dedifferentiation of PCa cells [85].