BCL2 and B-cell chronic lymphocytic leukemia: Several treatment options are available for CLL patients, which range from the watch-and-wait approach in the case of early-stage asymptomatic CLL to chemoimmunotherapy and targeted therapies with the most recent BCR signaling and Bcl-2 inhibitors, which have been proven effective in inducing prolonged remission in patients with advanced disease [12,121].