TIMP3 and Sorsby fundus dystrophy: Although the loss of glycosylation of TIMP3 is not a known molecular consequence of SFD-related mutation, ‘N-glycosylation/de-glycosylation systems may be a biologically important mechanism of post-translational re-modification of certain proteins [48,49] and in the case of SFD-deglycosylation due to as yet unknown factors may accelerate the progression of the disease.