Given the expression profiles recognized for these two biomarkers, our observations imply that, first, a pool of LRP-1 may be inducible or mobilized to contribute to efficient cell surface LRP-1-mediated An2 brain cancer cell internalization and, second, that a given MT1-MMP expression status may possibly dictate either intracellular LRP-1 trafficking to the cell surface or efficient cell surface LRP-1 functions. This evidence concerns the gene MMP14 and brain cancer.