Given that both MT1-MMP and LRP-1 are dynamically regulated through endocytic processes, and that differential gene expression profiles have been observed among the brain tumor tissues herein assessed (Figure 1), it remains to be established whether and how modulating intracellular trafficking of MT1-MMP and/or LRP-1 to the cell surface of low-grade to high-grade gliomas may affect the LRP-1-mediated An2 internalization process. Here, MMP14 is linked to central nervous system cancer.