This local signaling, especially in adipose tissue, further promotes inflammatory reactions by facilitating pro-inflammatory M-MDSCs (CD11b+Ly6G−Ly6Chi) and M1 macrophage polarization and inhibits reparative M-MDSCs (CD11b+Ly6G−Ly6Clow) and M2 macrophage polarization, ultimately contributing to the development of obesity-associated adipose tissue dysfunction and insulin resistance. The gene discussed is ITGAM; the disease is Insulin resistance.