To examine the role of myeloid-derived CCL5 in obesity-associated metabolic abnormalities, we used BM-specific BMT chimeras in which WT mice were irradiated and given the BM of WT or CCL5KO mice to generate L5KO/WT and WT/WT mice and examine whether the loss of CCL5 from hematopoietic cells could influence adipose tissue inflammation. The gene discussed is CCL5; the disease is obesity due to melanocortin 4 receptor deficiency.