CACNA1D and Bradycardia: We demonstrated that exon 22 encompassing arginine 930 is expressed in cardiac conduction tissue as well as in the brain, thus the p.R930H variant must result in dysfunctional Cav1.3 channels in the heart as well as in neurons, which is in line with the combined phenotype of epileptic seizures and bradycardia seen in R930H variant carriers.