In addition, a few de novo or somatic CACNA1D gene variants have been described in primary hyperaldosteronism, in aldosterone-producing adenomas and/or neurologic diseases, including epileptic seizures, autism spectrum disorder, developmental delay and attention deficit hyperactivity disorder (ADHD) -like symptoms [23,24,25,26]. The gene discussed is CACNA1D; the disease is Primary hyperaldosteronism.