As part of our ongoing research aimed at discovering new cancer-treatment and preventive agents [4,5,6,7], we found that cyclized guaiane-type sesquiterpenes and lignans from V. fauriei show cell-death-inducing activities against adriamycin-treated (ADR-treated) HeLa cells by inhibiting heat-shock protein (HSP), and through anti-proliferative effects against cancer stem cells (CSCs) and human astrocytoma cells [8]. This evidence concerns the gene HSP90B2P and cancer.