HIF1A and colitis: This HIF-1α-dependent enhanced ILC1 to ILC3 conversion and the strengthening of the ILC3/IL-22 driven prohomeostatic properties of the gut mucosa, whilst simultaneously, the ILC1 proinflammatory responses are dampened, results in a better outcome of disease in the context of DSS-induced colitis, shown by decreased histology scores and reduced weight loss in mice with HIF-1α KO in NKp46+ ILCs.