Via cell-fate mapping studies it was revealed that Salmonella infection may induce transdifferentiation of NKp46-ILC3s to IFNγ-producing ILC1s and that T-bet is necessary for conversion of NKp46+ RORγt+ ILCs from NKp46-ILC3s, since T-bet deficient mice (Tbx21−/−) lack NKp46+ T-bet+ RORγt+ ILCs and have reduced numbers of IFNγ-producing cells [42,99]. This evidence concerns the gene NCR1 and Salmonella Infections.