Importantly, ILC3-derived HB-EGF can limit acute and chronic intestinal inflammation and the authors report a reduced HB-EGF + ILC3 population also in the inflamed intestine of IBD patients, leading to the suggestion that loss of ILC3s can increase susceptibility of the intestine towards TNF-induced epithelial damage [82]. The gene discussed is GSTM1; the disease is inflammatory bowel disease.