APC and neurodegenerative disease: In particular, models of neurological injuries have shown that 3K3A-APC has neuroprotective effects manifesting as protection of blood–brain barrier (BBB) function, inhibition of neuroinflammation, inhibition of neuronal apoptosis, and regenerative effects targeting neuronal stem cells, highlighting the pleiotropic cytoprotective functions of 3K3A-APC in the brain and in neurodegenerative diseases [1,11,31].