Colorectal CSCs exhibit a remarkably lower level of ROS, a higher level of cysteine, glutathione and SLC7A11 compared to colorectal cancer cells; knockout of SLC7A11 can increase the ROS level and reduce the levels of cysteine and glutathione, subsequently attenuating the viability of colorectal CSCs [159]. The gene discussed is SLC7A11; the disease is colorectal cancer.