Additionally, (1) transcriptional analysis of muted Superoxide Dismutase1 (mSOD1) in iPSCs derived from ALS patients showed upregulation of UPR markers [93] and, (2) GGGGCC hexanucleotide expansion of C9ORF72 and ubiquitinated mutations within TDP-43 were identified in patients displaying both Fronto-Temporal Dementia (FTD) and ALS phenotypes, which suggests a genetic overlap between these disorders [94]. Here, TARDBP is linked to amyotrophic lateral sclerosis.