RRS1 and Huntington disease: Within the cytosol, mHtt aggregates may enhance toxicity whereas, in the nucleus, they sequester other proteins causing transcriptional dysregulation of CHOP, BiP, Homocysteine inducible ER protein with Ubiquitin-like domain1 (HerP), Apoptosis-regulatory Kinase1 (ASK1), and Ribosome Biogenesis regulator 1 Homolog (Rrs1), as found in post-mortem HD brains [9].