PGF and Hypertension: The molecular characteristics of preeclampsia are logically related to an imbalance between PlGF and sFlt-1; that is, a rise in sFlt-1 and a decrease in PlGF due to placental hypoxia or impaired perfusion in the placenta trigger systemic vascular and glomerular endothelial injury and lead to the onset of clinical symptoms, including hypertension and proteinuria [57,58].