PTEN and cancer: Other upstream stimuli of CCL5 are the enhancer of zeste homolog 2 (EZH2), which regulates macrophage-mediated cancer cell progression and migration; HER2 and PTEN, which are associated with cancer progression; and the angiotensin 2 (Ang2), which enhances the transcription of CCL5 and prolongs the immune response [40,41,42,43].