Recently published data showed that pancreatic cancer cells treated with the anti-cancer drug salicylanilide derivative Niclosamide (Nic) have increased phosphorylation/inhibition of GSK-3β leading to inhibition of non-canonical hedgehog/Gli cascade via upregulation of Sufu and Gli3 as well as stimulation of autophagy and causing pancreatic cancer cell death [55]. Here, GLI1 is linked to familial pancreatic carcinoma.