For example, nuclear localization of GSK-3β was demonstrated in 70% of human breast carcinomas and 73% of squamous cell head and neck carcinomas, whereas no detectable expression of nuclear GSK-3β was found in benign breast tissue and in benign salivary gland and other benign head and neck tissues [19]. The gene discussed is GSK3B; the disease is head and neck squamous cell carcinoma.