When comparing concentrations of major ligands (IL-2, IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-12 (p40), IL-12 (p70), IL-15, IL-27, GM-CSF, G-CSF) to type I cytokine receptors family between COVID-19 patients and healthy donors, we noted statistically significant elevation of IL-3 and IL-5 for the Wuhan strain, IL-6 for all the variants, but more so for the severe Alpha variant; IL-12 (p40) for the Wuhan strain and the Alpha variant. The gene discussed is IL27; the disease is COVID-19.