Inhibition of the RAS-RAF-MEK-ERK signaling of the heart cells may also exhibit adverse cardiovascular effects such as left ventricular systolic dysfunction [231,232], abrogation of protection against reperfusion injury [233] and pro-arrhythmia in the form of atrial tachyarrhythmias and prolongation of the QT interval [231]. Here, MAP2K7 is linked to cardiac arrhythmia.