Additionally, inhibition of proteasome degradation of G Protein-Coupled Receptor Kinase 2 (GRK2) protects against increased sensitivity to β-adrenergic stimulation, increased susceptibility to ventricular arrhythmias and inhibition of proteasome degradation of apoptosis repressor with caspase recruitment domain (ARC), which protects against cardiomyocyte apoptosis. The gene discussed is GRK2; the disease is Ventricular arrhythmia.