It is noteworthy that the complex oncogenic functions of POLR3C, PRKAB2, SETDB1, and GPATCH4 have not been studied yet, and because of being from the top correlating proteins with RACGAP1 in tumor tissues, their potential oncogenic roles and interacting network should be further studied to present clues for novel tumor treatment strategies. Here, SETDB1 is linked to neoplasm.