AQP1 and colorectal cancer: On the other hand, the oncogenes experienced a hypomethylation state as a mechanism for their activation to induce tumor progression [39]; for example, the hypomethylation state for the oncogenes AQP1, LINE-1, and ELMO3 was reported in salivary gland adenoid cystic carcinoma [40], colorectal cancer [41], and lung cancer [42], respectively.