We have previously shown that TRAP-induced phosphorylation of p38 MAP kinase, but not JNK, is followed by the phosphorylation of HSP27, leading to the release of phosphorylated HSP27 into the plasma [16] and that Akt in addition to p38 MAP kinase positively regulates the TRAP-induced release of phosphorylated HSP27 from human platelets in patients with DM [17]. This evidence concerns the gene MAPK8 and diabetes mellitus.