The most frequent variants in the SFN cohort were located in TRP genes, in total in fifteen patients (3.6%), which is consistent with data obtained for painful DN, where seven individuals (3.3%) had identified VUS TRP variants, three (1.4%) in TRPA1, three (1.4%) in TRPM8, one (0.5%) in TRPV4. The gene discussed is TRPV4; the disease is liver dysplastic nodule.