There were no significant differences in ApoM and S1P concentrations between HeFH patients with (VC) or without vascular complications (nonVC), including previous acute myocardial infarction, stroke, carotid artery atherosclerotic disease, or peripheral arterial disease (ApoM: VC 3.79 ± 0.62 vs. nonVC 3.73 ± 0.53 μg/mL, p = 0.7; S1P: VC 7.63 ± 1.08 vs. nonVC 7.75 ± 2.06 ng/mL, p = 0.8, respectively). The gene discussed is APOM; the disease is peripheral arterial disease.