APOM and stroke disorder: There were no significant differences in ApoM and S1P concentrations between HeFH patients with (VC) or without vascular complications (nonVC), including previous acute myocardial infarction, stroke, carotid artery atherosclerotic disease, or peripheral arterial disease (ApoM: VC 3.79 ± 0.62 vs. nonVC 3.73 ± 0.53 μg/mL, p = 0.7; S1P: VC 7.63 ± 1.08 vs. nonVC 7.75 ± 2.06 ng/mL, p = 0.8, respectively).