In the same vein, Pattel and colleagues reported that curcumin sensitizes CRC cells to FOLFOX by inhibiting EGFR family receptors and insulin-like growth factor-1 receptor (IGF-1R) [68,69,70], the overexpression of which has been related to chemoresistance in CRC [71,72]. This evidence concerns the gene IGF1R and colorectal carcinoma.