Finally, several studies have shown that curcumin can increase the intracellular accumulation of oxaliplatin and 5-fluorouracil in CRC cells by downregulating the P-gp [75,94] and ATP-binding cassette transporter G2 (ABCG2) [70] drug-efflux transporters both at the mRNA and protein levels. This evidence concerns the gene ABCG2 and colorectal carcinoma.