In fact, EMT was observed in chemotherapy-resistant CRC cell lines [57,81,82], while curcumin was able to revert this chemoresistance by downregulating EMT markers [83] through TGF-β/Smad2/3 signaling attenuation [84], by upregulating EMT suppressive miRNAs [85] or by downregulating the TET1-NKD2-WNT signaling pathway [86]. Here, TGFB1 is linked to colorectal carcinoma.