TLR3 and hepatitis A virus infection: For example, the effectiveness of anti-measles vaccination has been associated with TLR3-6 functional polymorphisms [8], the persistence of IgG responses to MenC vaccines has been associated with polymorphisms in the TLR3 and CD44 genes [9], the adaptive cytokine responses to rubella vaccination are affected by polymorphisms in the TLR, vitamin A, vitamin D receptor, and by innate immunity genes [10], and the antibody responses after vaccination with HBsAg and hepatitis A are influenced by a functional polymorphism in the promoter of IL10 gene [11].