Sultana et al., 2006, using a proteomic methodology, identified enolase, glyceraldehyde-3-phosphate dehydrogenase, ATP synthase alpha chain, carbonic anhydrase-II, and voltage-dependent anion channel-protein as the targets of nitration in AD hippocampus, a region that shows a extensive accumulation of amyloid beta-peptide, compared with the age-matched control brains [82]. This evidence concerns the gene APP and Alzheimer disease.