STK11 mutations are often associated with an “immune-cold” tumor microenvironment with low PD-L1 and T-cell densities, high granulocyte colony-stimulating factor and IL-8 family cytokines, and production of neutrophil-like cells and myeloid cell-recruiting chemokines such as IL-6 [98,99]. This evidence concerns the gene CXCL8 and neoplasm.