PCNA and familial pancreatic carcinoma: Now, recent studies have demonstrated several molecules that directly interact with KRAS regulate PCNA expression in lung, colorectal, and pancreatic cancers [72,73,74], and Caiola et al. [75] have shown that base-excision repair (BER) is involved in KRAS-mutated NSCLC, which results in PCNA ubiquitylation leading to the polymerase switch between replicative and translesion synthesis polymerases, initiating another important process contributing to crosslink repair [76].