Treatment with DNMT inhibitors including DAC was previously shown to upregulate crucial genes such as tumour suppressor genes [17,18,19], induce a viral mimicry response paving the way to immunotherapy [20,21,22,23], promote chemosensitivity [24,25,26] and reduce the colony-forming ability in cancer such as colorectal cancer (CRC) [20]. The gene discussed is DNMT1; the disease is cancer.