Furthermore, CISD2 knockout (CISD2 KO) mice display a panel of phenotypic features that are indicative of premature aging; these include a shortened lifespan accompanied by multiple age-associated organ dysfunctions (cardiac electromechanical dysfunction, sarcopenia, and degeneration of the nervous system), as well as dysregulation of whole body energy metabolism. The gene discussed is CISD2; the disease is sarcopenia.