PDC and isolated hyperferritinemia: These targets include the inhibition of DNA synthesis; free radical oxidative damage caused by iron and copper; lipid peroxidation; ferroptosis; modulation of the STEAP4 metalloreductase and metabolic pathways of oxidative damage affecting mitochondria; iron removal of macrophage iron overload affecting anticancer activity; hyperferritinemia; the modulation of hypoxia related to the role of hypoxia-inducible factor (HIF) and HIF PHD; and many others.