In Figure 2C, protein analysis by Western blot showed that the expression of early endosome antigen 1 (EEA1) and lysosomal-associated membrane protein 1 (LAMP-1) were both significantly increased in ASMCs of COPD patients (481.7% and 302.9%, respectively), when compared to control cells. Here, EEA1 is linked to chronic obstructive pulmonary disease.