NR1H4 and diabetic kidney disease: A study focusing on the role of FXR in a mouse model of diabetic nephropathy showed that treatment with the FXR ligand obeticholic acid induced the expression of renal CPT1, ACOX and CYP4A14, all three known to be under the regulation of PPARα, and which would result in increased fatty acid oxidation towards lipid catabolism under conditions of pathological cellular lipid accumulation [95].