Hepatic gene expression of mice with diet-induced NASH revealed a switch in the expression pattern of arachidonate-partitioning genes, notably the downregulation of members of the CYP2C family, which convert arachidonic acid to EETs, and upregulation of the epoxide hydrolase 2 (EPHX2), which inactivates EETs to dihydroxyeicosatrienoic acids. This evidence concerns the gene EPHX2 and metabolic dysfunction-associated steatohepatitis.