Indeed, the new diagnostic criteria require the use of cerebrospinal fluid (CSF) biomarkers, including total and hyperphosphorylated Tau protein as well as Aβ42 or Aβ42/Aβ40 ratio and positron emission tomography (PET) of τau and amyloid to attribute a probability (high, medium, or low) of the underlying AD-related neurodegenerative processes contributing to the clinical observations [1,22,72]. Here, MAPT is linked to Alzheimer disease.