Subpopulations that were significantly reduced in the LN patients were CD4+CD45RA+CCR7+ (naïve), CD4+CD45RA−CCR7+ (Central Memory, CM), CD4+CD45RA−CCR7− (EM), and CD4+CD45RA+CCR7− (EMRA) cells. This evidence concerns the gene CD4 and lobular neoplasia.