The ratio of CD4 exhausted/active cells (CD4+CD45RA+PD1+/CD4+CD45RA−PD1+) was significantly increased in the LN patients versus the HCs, 0.34 ± 0.3 versus 0.11 ± 0.1, respectively, p = 0.004, while the ratio in CD8 exhausted/active cells (CD8+CD45RA+PD1+/CD8+CD45RA−PD1+) was similar between the LN patients and HCs, 0.69 ± 0.7 vs. 1.2 ± 1.5, p = 0.2. The gene discussed is CD4; the disease is lobular neoplasia.