TNFSF13B and systemic lupus erythematosus: Moreover, in response to evidence that B cell depletion prevents or delays the onset of glomerulonephritis in lupus-prone mice [37,38] and induces complete or partial clinical remission in patients with lupus nephritis [39,40,41], B cell modulation with the BAFF inhibiting monoclonal antibody belimumab was recently shown successful in a lupus-nephritis-specific phase III clinical trial [19] and received approval for the treatment of this lupus manifestation.