Moreover, GCK could influence the occurrence and progress of osteoporosis through interacting with 138 potential target proteins at least, of which 16 targets were enriched in the osteoclast differentiation pathway based on KEGG analysis, and c-Fms-mediated osteoclast differentiation signaling may be one of the most important mechanisms for GCK in treating osteoporosis. The gene discussed is CSF1R; the disease is osteoporosis.