ORMDL3, an ER-resident transmembrane protein, regulates the activity of serine palmitoyltransferase (SPT), a rate-limiting enzyme in the biosynthesis of sphingolipids [64], ER stress, and unfolded protein response (UPR) [65,66], implying the role of ORMDL3 in asthma. This evidence concerns the gene ORMDL3 and asthma.